Predominance of IL-5-secreting drug-specific T cells in subgroups of patients with drug-induced delayed-type hypersensitivity reaction
نویسندگان
چکیده
Background Drug hypersensitivity reactions (DHRs) can be classified into IgE-induced, immediate type and T-cell mediated, delayed-type reactions. While the former are considered as Th2-driven immune responses characterized by IL-5secretion, the later are regarded as mainly provoked by IFN-gamma-producing Th1 cells. However, it has been suggested that delayed-type DHRs could also be elicited by IL-5 or a mixed T cell cytokine pattern.
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